Liver cancer is diagnosed in an estimated 42,000 people each year, primarily in men, and results in over 42,000 annual deaths in the United States. The liver is more often a site of metastases rather than the origin of cancer; however, there are several types of cancer that begin in the liver. Hepatocellular Carcinoma (HCC) is the most common type of liver cancer, causing nearly three-quarters of cases. Bile Duct Cancer, or Cholangiocarcinoma, represents 10% to 20% of cases and occurs in the bile duct. Angiosarcoma grows rapidly within the liver’s blood vessels; however, only about 1% of liver cancer is classified as Angiosarcoma.